豆科植物凝集素四级缔合的决定因素。
Determinants of quaternary association in legume lectins.
作者信息
Brinda K V, Mitra Nivedita, Surolia Avadhesha, Vishveshwara Saraswathi
机构信息
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
出版信息
Protein Sci. 2004 Jul;13(7):1735-49. doi: 10.1110/ps.04651004.
Abstract
It is well known that the sequence of amino acids in proteins code for its tertiary structure. It is also known that there exists a relationship between sequence and the quaternary structure of proteins. The question addressed here is whether the nature of quaternary association can be predicted from the sequence, similar to the three-dimensional structure prediction from the sequence. The class of proteins called legume lectins is an interesting model system to investigate this problem, because they have very high sequence and tertiary structure homology, with diverse forms of quaternary association. Hence, we have used legume lectins as a probe in this paper to (1) gain novel insights about the relationship between sequence and quaternary structure; (2) identify the sequence motifs that are characteristic of a given type of quaternary association; and (3) predict the quaternary association from the sequence motif.
摘要
众所周知，蛋白质中氨基酸的序列决定其三级结构。同样已知的是，序列与蛋白质的四级结构之间存在关联。这里要解决的问题是，四级缔合的性质是否能像从序列预测三维结构那样，从序列中预测出来。被称为豆科植物凝集素的这类蛋白质是研究这个问题的一个有趣的模型系统，因为它们具有非常高的序列和三级结构同源性，且四级缔合形式多样。因此，在本文中我们将豆科植物凝集素用作探针，以(1)获得关于序列与四级结构之间关系的新见解；(2)识别给定类型四级缔合所特有的序列基序；以及(3)从序列基序预测四级缔合。
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