Folwarczna Joanna, Janiec Waldemar, Barej Maria, Cegieła Urszula, Pytlik Maria, Kaczmarczyk-Sedlak Ilona
Department of Pharmacology, Medical University of Silesia, Jagiellońska 4, PL 41-200 Sosnowiec, Poland.
Pol J Pharmacol. 2004 May-Jun;56(3):337-43.
Nadroparin calcium is a low-molecular-weight heparin. Low-molecular-weight heparins have a number of advantages over standard heparin (heparin), but it is not clear if low-molecular-weight heparins have less effect on bones than heparin. Administration of heparin can lead to osteoporosis. The aim of the present study was to investigate the effects of nadroparin on the rat osseous system and compare them with those of heparin. The experiments were carried out on female Wistar rats (13-15 weeks old at the beginning of the experiment), divided into 5 groups: I. Control, II. Nadroparin (1000 anti-Xa IU/kg s.c. daily), III. Nadroparin (2000 anti-Xa IU/kg s.c. daily), IV. Heparin (1000 IU/kg s.c. daily), V. Heparin (2000 IU/kg s.c. daily). Nadroparin and heparin were administered for 4 weeks. Bone mass, mineral and calcium content, macrometric and histomorphometric parameters (endosteal and periosteal transverse growth, width of endosteal and periosteal osteoid, transverse cross-section area of the cortical bone in the diaphysis and of the marrow cavity in the tibia, width of epiphyseal cartilage, width of trabeculae in the epiphysis and metaphysis in the femur) were examined. The effect of heparin on the ratio of bone mineral content to bone mass was more pronounced than that of nadroparin. Nadroparin caused unfavorable changes in the investigated bone histomorphometric parameters, similar to those caused by heparin. Nadroparin and heparin caused disorder of bone formation and intensification of bone resorption in rats.
那屈肝素钙是一种低分子量肝素。与标准肝素相比，低分子量肝素有许多优势，但低分子量肝素对骨骼的影响是否小于肝素尚不清楚。肝素的使用可导致骨质疏松。本研究的目的是研究那屈肝素对大鼠骨骼系统的影响，并将其与肝素的影响进行比较。实验在雌性Wistar大鼠（实验开始时13 - 15周龄）身上进行，分为5组：I. 对照组；II. 那屈肝素（每日皮下注射1000抗Xa国际单位/千克）；III. 那屈肝素（每日皮下注射2000抗Xa国际单位/千克）；IV. 肝素（每日皮下注射1000国际单位/千克）；V. 肝素（每日皮下注射2000国际单位/千克）。那屈肝素和肝素给药4周。检测骨量、矿物质和钙含量、宏观和组织形态计量学参数（骨内膜和骨膜横向生长、骨内膜和骨膜类骨质宽度、骨干皮质骨和胫骨骨髓腔的横截面积、骨骺软骨宽度、股骨骨骺和干骺端小梁宽度）。肝素对骨矿物质含量与骨量比值的影响比那屈肝素更明显。那屈肝素在所研究的骨组织形态计量学参数上引起了与肝素相似的不利变化。那屈肝素和肝素导致大鼠骨形成紊乱和骨吸收增强。
