Dyr Wanda, Kostowski Wojciech
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02-957 Warszawa, Poland.
Pol J Pharmacol. 2004 May-Jun;56(3):359-65.
The Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP) lines were bred from Wistar foundation stock to obtain lines of rats that differ in their preference for ethanol (EtOH) solutions. The WHP line has met major criteria for an animal model of alcoholism. The WHP rats voluntarily drink excessive amounts of alcohol while the WLP rats consume negligible amounts of alcohol. These patterns of EtOH consumption are stable in time and independent of the manner of access to EtOH solutions. Notably, when exposed to the increasing EtOH concentrations both WHP and unselected Wistar rats gradually increased total EtOH intake. In contrast, WLP rats when exposed to the increasing concentrations of EtOH consumed almost negligible amounts of EtOH. Furthermore, the WHP rats show an increased responsiveness to the stimulatory effects of low dose of EtOH.
华沙高偏好（WHP）和华沙低偏好（WLP）品系是从Wistar基础种群培育而来，以获得对乙醇（EtOH）溶液偏好不同的大鼠品系。WHP品系符合酒精中毒动物模型的主要标准。WHP大鼠会自愿饮用过量酒精，而WLP大鼠摄入的酒精量可忽略不计。这些乙醇消费模式在时间上是稳定的，且与获取乙醇溶液的方式无关。值得注意的是，当暴露于浓度不断增加的乙醇中时，WHP大鼠和未选择的Wistar大鼠的乙醇总摄入量都逐渐增加。相比之下，WLP大鼠在暴露于浓度不断增加的乙醇中时，摄入的乙醇量几乎可忽略不计。此外，WHP大鼠对低剂量乙醇的刺激作用表现出更高的反应性。
