乙醇诱导青少年大鼠的运动活动与乙醇诱导的条件性位置偏好和条件性味觉厌恶的关系。
Ethanol-induced locomotor activity in adolescent rats and the relationship with ethanol-induced conditioned place preference and conditioned taste aversion.
机构信息
Instituto de Investigación Médica M. y M. Ferreyra INIMEC-CONICET, Friuli 2434, Córdoba, C.P. 5000, Argentina.
出版信息
Dev Psychobiol. 2013 May;55(4):429-42. doi: 10.1002/dev.21048. Epub 2012 May 16.
Abstract
Adolescent rats exhibit ethanol-induced locomotor activity (LMA), which is considered an index of ethanol's motivational properties likely to predict ethanol self-administration, but few studies have reported or correlated ethanol-induced LMA with conditioned place preference (CPP) by ethanol at this age. The present study assessed age-related differences in ethanol's motor stimulating effects and analyzed the association between ethanol-induced LMA and conventional measures of ethanol-induced reinforcement. Experiment 1 compared ethanol-induced LMA in adolescent and adult rats. Subsequent experiments analyzed ethanol-induced CPP and conditioned taste aversion (CTA) in adolescent rats evaluated for ethanol-induced LMA. Adolescent rats exhibit a robust LMA after high-dose ethanol. Ethanol-induced LMA was fairly similar across adolescents and adults. As expected, adolescents were sensitive to ethanol's aversive reinforcement, but they also exhibited CPP. These measures of ethanol reinforcement, however, were not related to ethanol-induced LMA. Spontaneous LMA in an open field was, however, negatively associated with ethanol-induced CTA.
摘要
青春期大鼠表现出乙醇诱导的运动活动（LMA），这被认为是乙醇的动机特性的指标，可能预测乙醇的自我给药，但很少有研究报告或相关的乙醇诱导的 LMA 与乙醇在这个年龄的条件性位置偏好（CPP）。本研究评估了乙醇对运动的刺激作用在年龄上的差异，并分析了乙醇诱导的 LMA 与乙醇诱导的强化的常规测量之间的关系。实验 1 比较了青春期和成年大鼠乙醇诱导的 LMA。随后的实验分析了青春期大鼠的乙醇诱导的 CPP 和条件性味觉厌恶（CTA），评估了乙醇诱导的 LMA。青春期大鼠在高剂量乙醇后表现出强烈的 LMA。乙醇诱导的 LMA 在青少年和成年人中相当相似。正如预期的那样，青少年对乙醇的厌恶强化很敏感，但他们也表现出 CPP。然而，这些乙醇强化的测量与乙醇诱导的 LMA 无关。然而，在开阔场中的自发 LMA 与乙醇诱导的 CTA 呈负相关。
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