Nasa Y, Hoque A N, Ichihara K, Abiko Y
Department of Pharmacology, Asahikawa Medical College, Japan.
Eur J Pharmacol. 1992 Mar 24;213(2):171-81. doi: 10.1016/0014-2999(92)90678-w.
The effects of pindolol and timolol on ischemia reperfusion damage were studied in isolated working rat hearts. Ischemia (15 min) decreased the mechanical function and the energy state, and increased the tissue levels of free fatty acids (FFA). During reperfusion (20 min), the mechanical function did not recover, but the energy state recovered incompletely, whereas FFA increased further. Pindolol (50 microM) accelerated recovery of the mechanical function and the energy state that had been decreased by ischemia during reperfusion, and inhibited the accumulation of FFA during ischemia and reperfusion, especially when it was applied during the whole period of reperfusion. Timolol (50 microM), however, did not accelerate recovery of the mechanical function and the energy state during reperfusion, although it attenuated FFA accumulation during reperfusion. The pindolol-induced recovery of the mechanical function during reperfusion was reduced by timolol. The results suggest that the intrinsic sympathomimetic activity of pindolol may play an important role, at least in part, in producing the cardioprotective effect, especially during reperfusion.
在离体工作的大鼠心脏中研究了吲哚洛尔和噻吗洛尔对缺血再灌注损伤的影响。缺血（15分钟）降低了机械功能和能量状态，并增加了游离脂肪酸（FFA）的组织水平。在再灌注期间（20分钟），机械功能未恢复，但能量状态不完全恢复，而FFA进一步增加。吲哚洛尔（50微摩尔）加速了再灌注期间因缺血而降低的机械功能和能量状态的恢复，并抑制了缺血和再灌注期间FFA的积累，特别是在整个再灌注期间应用时。然而，噻吗洛尔（50微摩尔）虽然减弱了再灌注期间FFA的积累，但并未加速再灌注期间机械功能和能量状态的恢复。吲哚洛尔诱导的再灌注期间机械功能的恢复被噻吗洛尔降低。结果表明，吲哚洛尔的内在拟交感活性可能至少部分地在产生心脏保护作用中起重要作用，特别是在再灌注期间。
