Innan Hideki
Human Genetics Center, School of Public Health, University of Texas Health Science Center, 1200 Hermann Pressler, Houston, TX 77030, USA.
Genes Genet Syst. 2004 Apr;79(2):65-75. doi: 10.1266/ggs.79.65.
A simple model for the evolutionary process of a pair of duplicated genes under concerted evolution is developed. The model considers mutation, recombination and gene conversion between two genes in a finite population. Based on diffusion theory, the expected amount of DNA variation within and between two genes are obtained. To investigate the pattern of DNA polymorphism, a coalescent tool to simulate patterns of polymorphism is developed. The theoretical results are well in agreement with polymorphism data in duplicated genes. The effect of selection on the pattern of polymorphism is also considered.
我们建立了一个简单的模型，用于描述在协同进化下一对重复基因的进化过程。该模型考虑了有限种群中两个基因之间的突变、重组和基因转换。基于扩散理论，我们得到了两个基因内部和之间DNA变异的预期量。为了研究DNA多态性模式，我们开发了一种用于模拟多态性模式的合并工具。理论结果与重复基因中的多态性数据高度吻合。我们还考虑了选择对多态性模式的影响。
