Toscano M F, Kampman Kenneth M., Beere Polly A., Bates Robert J., Demos Steven S., Anagnostopoulos C E
Cardiac Surgery Service, The University of Chicago, 950 East 59th Street, Chicago. Presently located in Rome, Italy.
Cardiovasc Dis. 1980 Mar;7(1):41-50.
The effectiveness of localized retrograde coronary venous perfusion (RCVP) in preventing or reversing myocardial ischemia after acute ligation of a coronary artery is described. Ten domestic pigs (Group I) underwent aorto left anterior coronary vein grafting with RCVP at systemic pressure. In another set of ten pigs (Group II), the coronary vein was similarly grafted, but the proximal end of the graft was perfused with oxygenated blood by means of an external pump at reduced pressure and flow. In both groups, RCVP successfully reversed the mechanical or electrical effects produced by 2 to 5 minutes of acute arterial ligation. After several hours, Group I animals showed evidence of acute ischemia and developing infarction. Group II animals, however, were maintained for 7 hours or more with regional RCVP and no evidence of ischemia. Retrograde coronary venous perfusion at reduced pressure may be more effective than perfusion at systemic pressure in providing myocardial blood flow.
本文描述了局部逆行冠状静脉灌注（RCVP）在预防或逆转冠状动脉急性结扎后心肌缺血方面的有效性。十只家猪（第一组）在体循环压力下进行了主动脉-左前冠状静脉移植并进行RCVP。在另一组十只猪（第二组）中，同样进行了冠状静脉移植，但移植的近端通过外部泵在减压和低流量下灌注含氧血液。在两组中，RCVP均成功逆转了急性动脉结扎2至5分钟所产生的机械或电效应。数小时后，第一组动物出现急性缺血和梗死进展的迹象。然而，第二组动物通过局部RCVP维持了7小时或更长时间，且无缺血迹象。减压逆行冠状静脉灌注在提供心肌血流方面可能比体循环压力灌注更有效。
