• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

核酸双链体中2'-N-（芘-1-基）甲基-2'-氨基-LNA单体之间的链间通讯：完全互补性的方向控制和信号传导

Interstrand communication between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers in nucleic acid duplexes: directional control and signalling of full complementarity.

作者信息

Hrdlicka Patrick J, Babu B Ravindra, Sørensen Mads D, Wengel Jesper

机构信息

Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark.

出版信息

Chem Commun (Camb). 2004 Jul 7(13):1478-9. doi: 10.1039/b404446k. Epub 2004 Jun 4.

DOI:10.1039/b404446k
PMID:15216339
Abstract

Very efficient interstrand communication systems in nucleic acid duplexes, based on pyrene excimer formation between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers, demonstrate the versatility of functionalized 2'-amino-LNA monomers for Angstrom-scale chemical engineering.

摘要

基于2'-N-(芘-1-基)甲基-2'-氨基-LNA单体之间芘激基缔合物形成的核酸双链体中非常高效的链间通信系统，证明了功能化2'-氨基-LNA单体在埃级化学工程中的多功能性。

相似文献

1
Interstrand communication between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers in nucleic acid duplexes: directional control and signalling of full complementarity.核酸双链体中2'-N-（芘-1-基）甲基-2'-氨基-LNA单体之间的链间通讯：完全互补性的方向控制和信号传导
Chem Commun (Camb). 2004 Jul 7(13):1478-9. doi: 10.1039/b404446k. Epub 2004 Jun 4.
2
Multilabeled pyrene-functionalized 2'-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays.用于均相荧光分析中核酸检测的多标记芘功能化2'-氨基-LNA探针。
J Am Chem Soc. 2005 Sep 28;127(38):13293-9. doi: 10.1021/ja052887a.
3
Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies.易变性核酸设计中的锁核酸和嵌入核酸：热稳定性研究
Chembiochem. 2004 Dec 3;5(12):1673-9. doi: 10.1002/cbic.200400222.
4
Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2'-amino-LNA: high-affinity hybridization and fluorescence sensing.基于连接到 2'-氨基-LNA 的 1-、2- 和 4-（苯乙炔基）芘的 DNA 双链体中的新型链间通信系统：高亲和力杂交和荧光传感。
Chem Commun (Camb). 2010 Nov 28;46(44):8362-4. doi: 10.1039/c0cc03026k. Epub 2010 Oct 4.
5
Modulation of pyrene fluorescence in DNA probes depends upon the nature of the conformationally restricted nucleotide.芘荧光在DNA探针中的调制取决于构象受限核苷酸的性质。
J Org Chem. 2008 Apr 4;73(7):2829-42. doi: 10.1021/jo702747w. Epub 2008 Mar 11.
6
Highly fluorescent conjugated pyrenes in nucleic acid probes: (phenylethynyl)pyrenecarbonyl-functionalized locked nucleic acids.核酸探针中高荧光共轭芘：（苯乙炔基）芘羰基官能化的锁核酸
Chemistry. 2008;14(35):11010-26. doi: 10.1002/chem.200801077.
7
Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2'-amino-alpha-l-LNA.使用芘功能化的2'-氨基-α-L-锁核酸靶向混合序列双链DNA。
Chem Commun (Camb). 2005 Sep 14(34):4279-81. doi: 10.1039/b506986f. Epub 2005 Jul 21.
8
2'-N-(pyren-1-yl)acetyl-2'-amino-alpha-L-LNA: synthesis and detection of single nucleotide mismatches in DNA and RNA targets.2'-N-（芘-1-基）乙酰基-2'-氨基-α-L-锁核酸：DNA和RNA靶标中单个核苷酸错配的合成与检测
Chembiochem. 2007 Jul 9;8(10):1122-5. doi: 10.1002/cbic.200700144.
9
Conformationally controlled high-affinity targeting of RNA or DNA by novel 2'-amino-DNA/LNA mixmers and pyrenyl-functionalized 2'-amino-DNA.
Org Biomol Chem. 2004 Oct 21;2(20):2885-7. doi: 10.1039/B411626G. Epub 2004 Sep 13.
10
Unlocked nucleic acids with a pyrene-modified uracil: synthesis, hybridization studies, fluorescent properties and i-motif stability.带有芘修饰尿嘧啶的非锁核酸：合成、杂交研究、荧光性质和 i 型发夹结构稳定性。
Chembiochem. 2014 Jan 3;15(1):146-56. doi: 10.1002/cbic.201300567.

引用本文的文献

1
Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications.超越核糖与磷酸：用于结构功能研究及治疗应用的特定核酸修饰
Beilstein J Org Chem. 2021 Apr 28;17:908-931. doi: 10.3762/bjoc.17.76. eCollection 2021.
2
Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers.使用具有1-、2-或4-芘基官能化的O2'-烷基化RNA单体的链间拉链的能量激活双链体识别双链DNA。
Org Biomol Chem. 2014 Oct 21;12(39):7758-73. doi: 10.1039/c4ob01183j. Epub 2014 Aug 21.
3
C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stability.
C5-炔基官能化的α-L-锁核酸：合成、热变性实验及酶稳定性
J Org Chem. 2014 Jun 6;79(11):5062-73. doi: 10.1021/jo5006153. Epub 2014 May 13.
4
Recognition of mixed-sequence DNA duplexes: design guidelines for invaders based on 2'-O-(pyren-1-yl)methyl-RNA monomers.混合序列 DNA 双链体的识别：基于 2'-O-(苝-1-基)甲基-RNA 单体的入侵物设计准则。
J Org Chem. 2013 Dec 6;78(23):12040-8. doi: 10.1021/jo402085v. Epub 2013 Nov 20.
5
Rapid genotyping using pyrene-perylene locked nucleic acid complexes.使用芘-苝锁核酸复合物进行快速基因分型。
Artif DNA PNA XNA. 2013 Apr-Jun;4(2):58-68. doi: 10.4161/adna.25903.
6
Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.鉴定和表征第二代入侵锁核酸（LNA），用于双链 DNA 的混合序列识别。
J Org Chem. 2013 Oct 4;78(19):9560-70. doi: 10.1021/jo4015936. Epub 2013 Sep 25.
7
DNA-multichromophore systems.DNA-多生色团系统
Chem Rev. 2012 Jul 11;112(7):4221-45. doi: 10.1021/cr100351g. Epub 2012 Mar 16.
8
Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology.芘基化寡核苷酸和锁核酸 (LNA)：基础研究、诊断和纳米技术的工具。
Chem Soc Rev. 2011 Dec;40(12):5771-88. doi: 10.1039/c1cs15014f. Epub 2011 Apr 13.
9
Invader LNA: efficient targeting of short double stranded DNA.入侵性 LNA：高效靶向短双链 DNA。
Org Biomol Chem. 2010 May 7;8(9):2028-36. doi: 10.1039/b923465a. Epub 2010 Mar 4.
10
Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.功能化的2'-氨基-α-L-锁核酸：用于DNA靶向的嵌入剂的定向定位。
J Org Chem. 2009 Feb 6;74(3):1070-81. doi: 10.1021/jo802037v.