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Conformationally controlled high-affinity targeting of RNA or DNA by novel 2'-amino-DNA/LNA mixmers and pyrenyl-functionalized 2'-amino-DNA.

作者信息

Kalra Neerja, Babu B Ravindra, Parmar Virinder S, Wengel Jesper

机构信息

Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Denmark.

出版信息

Org Biomol Chem. 2004 Oct 21;2(20):2885-7. doi: 10.1039/B411626G. Epub 2004 Sep 13.

DOI:10.1039/B411626G
PMID:15480448
Abstract

9-Mer DNA sequences containing 2'-N-methyl-2'-N-(pyren-1-ylmethyl)-2'-amino-DNA monomers display significantly increased affinity towards DNA complements whereas the corresponding 2'-amino-DNA monomer has a detrimental effect on duplex stability. These effects are efficiently reversed by incorporation of four LNA nucleotides inducing a B-DNA to A-DNA conformational change.

摘要

相似文献

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2
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