爱泼斯坦-巴尔病毒潜伏基因在口腔上皮中的表达：口腔毛状白斑发病机制的决定因素

Expression of Epstein-Barr virus latent genes in oral epithelium: determinants of the pathogenesis of oral hairy leukoplakia.

作者信息

Walling Dennis M, Ling Paul D, Gordadze Alexey V, Montes-Walters Miguel, Flaitz Catherine M, Nichols C Mark

机构信息

Division of Infectious Diseases, Department of Internal Medicine, and Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

出版信息

J Infect Dis. 2004 Jul 15;190(2):396-9. doi: 10.1086/422039. Epub 2004 Jun 11.

DOI:10.1086/422039

PMID:15216478

Abstract

This retrospective study examined expression of Epstein-Barr virus (EBV) latent genes in oral epithelium from human immunodeficiency virus-seropositive subjects, to identify genes associated with the pathogenesis of oral hairy leukoplakia (HLP). Transcription of EBV latent genes was detected in tissues with productive EBV replication and, also, in normal oral epithelial tissues without EBV replication. Expression of the EBV EBNA-2 open-reading frame in oral epithelium was identified as an important cofactor associated with the pathogenesis of HLP. In vitro experiments suggested that a recombinant variant of the EBNA-2 gene may play a role in the pathogenesis of HLP, through modulation of EBNA-2 protein function.

摘要

这项回顾性研究检测了人类免疫缺陷病毒血清阳性受试者口腔上皮中EB病毒（EBV）潜伏基因的表达情况，以确定与口腔毛状白斑（HLP）发病机制相关的基因。在有活跃EBV复制的组织以及无EBV复制的正常口腔上皮组织中均检测到了EBV潜伏基因的转录。EBV EBNA-2开放阅读框在口腔上皮中的表达被确定为与HLP发病机制相关的一个重要辅助因子。体外实验表明，EBNA-2基因的重组变体可能通过调节EBNA-2蛋白功能在HLP发病机制中发挥作用。