Kang Myung-Soo, Kieff Elliott
1] Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Samsung Medical Center, Sungkyunkwan University, Seoul, Korea [2] Samsung Biomedical Research Institute (SBRI), Samsung Medical Center, Sungkyunkwan University, Seoul, Korea.
Department of Medicine, Brigham and Women's Hospital, Program in Virology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
Exp Mol Med. 2015 Jan 23;47(1):e131. doi: 10.1038/emm.2014.84.
Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited latent genes, is consistent with the notion that EBV latent genes are important for malignant cell growth. While the EBV-encoded nuclear antigen-1 (EBNA-1) and latent membrane protein-2A (LMP-2A) are critical, the EBNA-leader proteins, EBNA-2, EBNA-3A, EBNA-3C and LMP-1, are individually essential for in vitro transformation of primary B cells to lymphoblastoid cell lines. EBV-encoded RNAs and EBNA-3Bs are dispensable. In this review, the roles of EBV latent genes are summarized.
潜伏性爱泼斯坦-巴尔病毒（EBV）感染在引发多种人类疾病中起着重要作用。这些病毒基因组在所有恶性细胞中持续存在，但仅表达有限的潜伏基因，这与EBV潜伏基因对恶性细胞生长很重要的观点一致。虽然EBV编码的核抗原-1（EBNA-1）和潜伏膜蛋白-2A（LMP-2A）至关重要，但EBNA前导蛋白、EBNA-2、EBNA-3A、EBNA-3C和LMP-1对于将原代B细胞体外转化为淋巴母细胞系各自都是必不可少的。EBV编码的RNA和EBNA-3B是可有可无的。在本综述中，总结了EBV潜伏基因的作用。
