Müller-Hagen Gerit, Beinert Thomas, Sommer Anette
Charité - Universitary Medicine Berlin, Campus Virchow, Department of Internal Medicine/Infectious Diseases, Humboldt-University, Augustenburger Platz 1, 13353 Berlin, Germany.
Curr Opin Drug Discov Devel. 2004 May;7(3):290-303.
Lung cancer is the most common cancer in the world. In the majority of cases, a tumor will have already become disseminated at the time of diagnosis, and extensive efforts to improve diagnosis and therapy have had no major success so far. Lung cancer gene expression profiling provides novel diagnostic and prognostic markers and a basis for targeted therapies involving small-molecule and antibody-based approaches. To enhance further research and to translate knowledge gained at the molecular level into novel therapeutic concepts, this review summarizes gene expression analyses of lung cancer performed at the RNA level using suppression subtractive hybridization, serial analysis of gene expression and cDNA and oligonucleotide microarrays, and discusses major findings.
肺癌是全球最常见的癌症。在大多数情况下，肿瘤在诊断时就已经发生扩散，迄今为止，为改善诊断和治疗所做的大量努力并未取得重大成功。肺癌基因表达谱分析提供了新的诊断和预后标志物，并为涉及小分子和基于抗体方法的靶向治疗奠定了基础。为了进一步加强研究并将在分子水平获得的知识转化为新的治疗理念，本综述总结了使用抑制性消减杂交、基因表达序列分析以及cDNA和寡核苷酸微阵列在RNA水平上进行的肺癌基因表达分析，并讨论了主要研究结果。
