绿茶（茶树）与丁基羟基茴香醚联合使用时杀菌活性增强。

Increased microbicidal activity of green tea (Camellia sinensis) in combination with butylated hydroxyanisole.

作者信息

Simonetti G, Simonetti N, Villa A

机构信息

University of Rome La Sapienza, Institute of Microbiology, Faculty of Pharmacy, Rome, Italy.

出版信息

J Chemother. 2004 Apr;16(2):122-7. doi: 10.1179/joc.2004.16.2.122.

DOI:10.1179/joc.2004.16.2.122

PMID:15216944

Abstract

We have demonstrated that green tea (Camellia sinensis) shows increased antimicrobial activity against bacteria and fungi when used in combination with butylated hydroxyanisole (BHA). Glycolic extract taken from green tea showed only limited activity against Streptococcus mutans and no activity against Candida albicans and certain strains of Escherichia coli. BHA, at non inhibitory concentrations, increased the microbicidal activity of green tea against 10(10) S. mutans (p<0.01), non-susceptible E. coli (p<0.01) and C. albicans (p<0.01). Green tea in combination with BHA reduced the hydrophobicity of S. mutans (p<0.01) and greatly inhibited (p<0.001) the formation of hyphae in C. albicans. The increased antimicrobial activity of green tea is related to an impairment of the barrier function in microorganisms and a depletion of thiol groups. The increased activity of green tea as an oral antimicrobial product is discussed.

摘要

我们已经证明，绿茶（茶树）与丁基羟基茴香醚（BHA）联合使用时，对细菌和真菌的抗菌活性增强。从绿茶中提取的乙醇提取物对变形链球菌的活性有限，对白色念珠菌和某些大肠杆菌菌株无活性。在非抑制浓度下，BHA增强了绿茶对10¹⁰变形链球菌（p<0.01）、非敏感大肠杆菌（p<0.01）和白色念珠菌（p<0.01）的杀菌活性。绿茶与BHA联合使用降低了变形链球菌的疏水性（p<0.01），并极大地抑制了白色念珠菌中菌丝的形成（p<0.001）。绿茶抗菌活性的增强与微生物屏障功能的损害和巯基的消耗有关。本文讨论了绿茶作为口腔抗菌产品活性增强的情况。