Chansritrakul Sonchai, Eiam-Ong Somchai, Kansanabuch Talerngsak, Wathanavaha Arpar, Ruxrungtham Kiat
Nephrology Unit, Chon Buri Province Hospital.
J Med Assoc Thai. 2004 Apr;87(4):389-94.
Cell-mediated immune response (CMIR) was studied in 16 ESRD (end-stage renal disease) patients prior to and after 6 months of treatment with CAPD (continuous ambulatory peritoneal dialysis). Quantitative assessment of the CMI system showed that the mean values of number and percentage of total lymphocyte count, CD4, CD8, and CD4/CD8 in ESRD patients were lower than in the normal population. Such values, however, were significantly increased after 6 months of CAPD treatment. To determine qualitative function of the CMI system, both in vitro (PHA stimulation test) and in vivo (multi CMI skin test) tests were examined. There were no significant changes in the results of PHA stimulation test after 6 months of CAPD treatment. In multi CMI skin test, the number of patients converting from negative to positive result was obviously noted following CAPD therapy for 6 months. In conclusion, both quantitative and qualitative CMI impairment existing in ESRD patients could be corrected, although not completely, by 6-month CAPD treatment.
在16例终末期肾病（ESRD）患者接受持续性非卧床腹膜透析（CAPD）治疗6个月前后，对其细胞介导的免疫反应（CMIR）进行了研究。对细胞介导免疫（CMI）系统的定量评估显示，ESRD患者的总淋巴细胞计数、CD4、CD8以及CD4/CD8的数量和百分比的平均值低于正常人群。然而，经过6个月的CAPD治疗后，这些数值显著增加。为了确定CMI系统的定性功能，对体外（PHA刺激试验）和体内（多项CMI皮肤试验）试验均进行了检测。CAPD治疗6个月后，PHA刺激试验结果无显著变化。在多项CMI皮肤试验中，明显观察到在接受CAPD治疗6个月后，从阴性结果转为阳性结果的患者数量有所增加。总之，6个月的CAPD治疗虽不能完全纠正ESRD患者存在的CMI定量和定性损伤，但可起到一定改善作用。
