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FR901512, a novel HMG-CoA reductase inhibitor produced by an agonomycetous fungus No. 14919. II. Taxonomy of the producing organism, fermentation, isolation and physico-chemical properties.

作者信息

Hatori Hidetaka, Sato Bunji, Sato Ikuko, Shibata Toshihiro, Tsurumi Yasuhisa, Sakamoto Kazutoshi, Takase Shigehiro, Ueda Hirotsugu, Hino Motohiro, Fujii Takashi

机构信息

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan.

出版信息

J Antibiot (Tokyo). 2004 Apr;57(4):264-70. doi: 10.7164/antibiotics.57.264.

DOI:10.7164/antibiotics.57.264
PMID:15217191
Abstract

Novel compounds FR901512 and FR901516 were isolated from the fermentation broth of agonomycete strain No. 14919. FR901512 and FR901516 possess unique tetralin ring in their structure. These compounds were potent inhibitors of the cholesterol synthesis in human hepatoma cell line Hep G2. FR901512 shows strong 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitory activity with an IC50 value of 0.95 nM.

摘要

相似文献

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引用本文的文献

1
Knockout of the SREBP system increases production of the polyketide FR901512 in filamentous fungal sp. No. 14919 and lovastatin in Aspergillus terreus ATCC20542.敲除 SREBP 系统可增加丝状真菌 No. 14919 中多酮类 FR901512 和土曲霉 ATCC20542 中洛伐他汀的产量。
Appl Microbiol Biotechnol. 2018 Feb;102(3):1393-1405. doi: 10.1007/s00253-017-8685-7. Epub 2017 Dec 21.
2
Genome Sequence of the Fungal Strain 14919 Producing 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor FR901512.产3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂FR901512的真菌菌株14919的基因组序列
Genome Announc. 2017 Apr 6;5(14):e00129-17. doi: 10.1128/genomeA.00129-17.