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FR171456，一种由微小孢子菌15604号菌株产生的新型胆固醇合成抑制剂。I. 分类学、发酵、分离、理化性质

FR171456, a novel cholesterol synthesis inhibitor produced by Sporormiella minima No. 15604. I. Taxonomy, fermentation, isolation, physico-chemical properties.

作者信息

Hatori Hidetaka, Shibata Toshihiro, Tsurumi Yasuhisa, Nakanishi Tomoko, Katsuoka Masaaki, Ohtsu Yoshihiro, Sakamoto Kazutoshi, Takase Shigehiro, Ueda Hirotsugu, Hino Motohiro, Fujii Takashi

机构信息

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan.

出版信息

J Antibiot (Tokyo). 2004 Apr;57(4):253-9. doi: 10.7164/antibiotics.57.253.

DOI:10.7164/antibiotics.57.253
PMID:15217189
Abstract

FR171456 and FR173945, novel and potent cholesterol synthesis inhibitors, have been isolated from the fermentation broth of a fungal strain No. 15604. This strain was identified Sporormiella minima from its mycological characteristics. FR171456 and FR173945 strongly inhibited cholesterol synthesis in human hepatoma cell line Hep G2. These compounds also have in vitro antifungal activity against Candida albicans and Aspergillus fumigatus.

摘要

FR171456和FR173945是新型强效胆固醇合成抑制剂，从真菌菌株15604的发酵液中分离得到。根据其真菌学特征，该菌株被鉴定为微小孢子菌。FR171456和FR173945强烈抑制人肝癌细胞系Hep G2中的胆固醇合成。这些化合物对白色念珠菌和烟曲霉也具有体外抗真菌活性。

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