Prakash Chaturvedula V S, Hecht Sidney M, Gao Zhijie, Jones Shannon H, Feng Xizhi, Kingston David G I
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA.
J Nat Prod. 2004 Jun;67(6):964-7. doi: 10.1021/np030507y.
Bioassay-directed fractionation of a methyl ethyl ketone extract of the roots of Endlicheria aff. resulted in the isolation of four new neolignans (1-4) and eight known compounds, namely, canellin A (5), canellin C (6), 3'-methoxyguianin (7), (7S,8R,1'S,5'S,6'R)-Delta(2',8')-3',6'-dihydroxy-5'-methoxy-3,4-methylenedioxy-4'-oxo-8.1',7.5'-neolignan (8), armenin-B (9), dillapiole (10), 1-allyl-2,6-dimethoxy-3,4-methylenedioxybenzene (11), and omega-hydroxyisodillapiole (12). The structures of the new compounds (1-4) were established as (7S,8R,1'S,5'S,6'R)-Delta(2',8')-5',6'-dihydroxy-3'-methoxy-3,4-methylenedioxy-4'-oxo-8.1',7.5'-neolignan, (7S,8R,1'S,5'S,6'R)-Delta(2',8')-3',5',6'-trihydroxy-3,4-methylenedioxy-4'-oxo-8.1',7.5'-neolignan, 2,4-dimethoxy-5,6-methylenedioxy-1-(2-propenyl)benzene, and 2,6-dimethoxy-3,4-methylenedioxycinnamyl alcohol, respectively, on the basis of spectroscopic interpretation.
对近恩氏木属植物根部的甲基乙基酮提取物进行生物活性导向分离，得到了4个新的新木脂素（1 - 4）和8个已知化合物，即卡尼林A（5）、卡尼林C（6）、3'-甲氧基愈创木酚（7）、(7S,8R,1'S,5'S,6'R)-Δ(2',8')-3',6'-二羟基-5'-甲氧基-3,4-亚甲二氧基-4'-氧代-8.1',7.5'-新木脂素（8）、阿尔门宁-B（9）、莳萝脑（10）、1-烯丙基-2,6-二甲氧基-3,4-亚甲二氧基苯（11）和ω-羟基异莳萝脑（12）。根据光谱解析，新化合物（1 - 4）的结构分别确定为(7S,8R,1'S,5'S,6'R)-Δ(2',8')-5',6'-二羟基-3'-甲氧基-3,4-亚甲二氧基-4'-氧代-8.1',7.5'-新木脂素、(7S,8R,1'S,5'S,6'R)-Δ(2',8')-3',5',,6'-三羟基-3,4-亚甲二氧基-4'-氧代-8.1',7.5'-新木脂素、2,4-二甲氧基-5,6-亚甲二氧基-1-(2-丙烯基)苯和2,6-二甲氧基-3,4-亚甲二氧基肉桂醇。
