Teng Wen-Yuh, Huang Yu-Ling, Huang Ray-Ling, Chung Ren-Shih, Chen Chien-Chih
Department of Agricultural Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan, Republic of China.
J Nat Prod. 2004 Jun;67(6):1014-7. doi: 10.1021/np049933p.
Imperatorin (1) was metabolized by Aspergillus flavus, in growth media, to give five metabolites. On the basis of their physical data, the structures of the five metabolites were elucidated as xanthotoxol (2), E-trichoclin (3), Z-trichoclin (4), E-imperatorin acid (5), and Z-imperatorin acid (6); among these, 4, 5, and 6 were characterized as new coumarins. The five metabolites 2-6 were tested for anti-hepatitis B virus activity in vitro and found to be less active than the parent compound 1.
欧前胡素（1）在黄曲霉生长培养基中被代谢，产生了五种代谢产物。根据它们的物理数据，确定这五种代谢产物的结构分别为花椒毒素（2）、E-异紫花前胡内酯（3）、Z-异紫花前胡内酯（4）、E-欧前胡素酸（5）和Z-欧前胡素酸（6）；其中，4、5和6被鉴定为新的香豆素。对这五种代谢产物2-6进行了体外抗乙型肝炎病毒活性测试，发现它们的活性低于母体化合物1。
