近交系大鼠品系中对自身免疫复合物性肾小球肾炎易感性的遗传控制。
Genetic control of susceptibility to autologous immune complex glomerulonephritis in inbred rat strains.
作者信息
Stenglein B, Thoenes G H, Günther E
出版信息
Clin Exp Immunol. 1978 Jul;33(1):88-94.
Twelve inbred rat strains were tested for their susceptibility to autologous immune complex glomerulonephritis (AIC) after a single injection of a primary tubular epithelial fraction emulsified in Freund's complete adjuvant. Six strains (Lewis, AS, BDV, L.BDV, AS2, L.AS2) showed high responsiveness in terms of proteinuria and immunohistological changes, which could be observed after 3 months. Strains BN, AVN and DA were completely resistant, even after 6 months of observation. An additional adjuvant (pertussis vaccine) did not break non-responsiveness in one of these strains (BN). Strains which share the Lewis strain genetic background (L.BN, L.AVN and L.WP) seemed to be at least weakly susceptible to AIC. A close association between susceptibility and the major histocompatibility haplotypes is demonstrated in segregation studies involving Lewis, L.BN and BN rats. A threshold model of AIC susceptibility, based on the action of major histocompatibility-linked genes and background genes, is suggested.
在单次注射弗氏完全佐剂乳化的原发性肾小管上皮部分后，对12个近交系大鼠品系进行自体免疫复合物肾小球肾炎（AIC）易感性测试。6个品系（Lewis、AS、BDV、L.BDV、AS2、L.AS2）在蛋白尿和免疫组织学变化方面表现出高反应性，3个月后即可观察到。BN、AVN和DA品系完全具有抗性，即使经过6个月的观察也是如此。额外的佐剂（百日咳疫苗）并未打破其中一个品系（BN）的无反应性。具有Lewis品系遗传背景的品系（L.BN、L.AVN和L.WP）似乎至少对AIC有轻度易感性。在涉及Lewis、L.BN和BN大鼠的分离研究中，证明了易感性与主要组织相容性单倍型之间的密切关联。基于主要组织相容性相关基因和背景基因的作用，提出了AIC易感性的阈值模型。
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