近交系大鼠品系中实验性变应性脑脊髓炎易感性与主要组织相容性系统之间的关联。
Association between susceptibility to experimental allergic encephalomyelitis and the major histocompatibility system in congenic rat strains.
作者信息
Günther E, Odenthal H, Wechsler W
出版信息
Clin Exp Immunol. 1978 Jun;32(3):429-34.
Abstract
The genetics of the inducibility of experimental allergic encephalomyelitis (EAE) was studied in ten inbred rat strains by injection of guinea pig spinal cord in complete Freund's adjuvant. LEW rats were highly susceptible and AS2, AVN, BDV and BN rats were poorly susceptible. Congenic strains which carried the major histocompatibility haplotype of the poorly susceptible strains on the genetic background of the susceptible LEW strain were only moderately susceptible. It is concluded that major histocompatibility-linked genes exert a strong influence on the susceptibility to EAE, but that genetic background genes are also involved.
摘要
通过在完全弗氏佐剂中注射豚鼠脊髓，对10个近交系大鼠品系实验性变应性脑脊髓炎（EAE）的诱导性遗传学进行了研究。LEW大鼠高度易感，而AS2、AVN、BDV和BN大鼠则不易感。在易感的LEW品系遗传背景上携带不易感品系主要组织相容性单倍型的同类系大鼠仅为中度易感。结论是，主要组织相容性连锁基因对EAE易感性有强烈影响，但遗传背景基因也参与其中。
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