Owen J P, Lavelle M I
Clin Radiol. 1978 Sep;29(5):535-40. doi: 10.1016/s0009-9260(78)80046-4.
Iocetamic acid (Cholebrin) and calcium ipodate (Solubiloptin) were randomly allocated to two groups of 50 patients. Each patient completed a detailed questionnaire for side effects. There was no significant difference between the contrast media in their ability to opacify the gallbladder. Cholebrin was superior to Solubiloptin in opacifying the common bile duct in the presence of abnormal liver function, but there was no difference when liver function was normal. Palpitations were significantly higher with Solubiloptin (P = 0.01) but the incidences of other side effects showed no significant differences. Unabsorbed contrast residues were noted in similar frequency with both media. A high incidence of chronic cholecystitis was found in patients with non-opacified gallbladders and in those with gallstones.
碘番酸（胆影酸）和碘泊酸钙（胆影葡胺）被随机分配到两组，每组50例患者。每位患者都填写了一份关于副作用的详细问卷。两种造影剂在使胆囊显影的能力上没有显著差异。在肝功能异常的情况下，胆影酸在使胆总管显影方面优于胆影葡胺，但肝功能正常时两者没有差异。使用胆影葡胺时心悸发生率显著更高（P = 0.01），但其他副作用的发生率没有显著差异。两种造影剂未吸收的造影剂残留出现频率相似。在胆囊未显影的患者和有胆结石的患者中发现慢性胆囊炎的发生率很高。
