van Meurs J C, Schwoerer J, Schwartz B, Mulder P G, Meiselmann H J, Johnson C S
Doheny Eye Institute, USC Department of Ophthalmology, Los Angeles.
Graefes Arch Clin Exp Ophthalmol. 1992;230(5):442-5. doi: 10.1007/BF00175930.
We tested retinal vessel autoregulation in 16 sickle cell patients and 6 controls by computer-assisted measurements of constriction of the superior and inferior temporal veins and arteries after pure oxygen breathing. Compared to the controls and corrected for age, we found a decrease of vasoconstriction in three of the four vessels measured in the sickle cell group, which was statistically significant only for the superior temporal artery (P 0.009). The number of patients was too small to allow a separate analysis of possible contributory factors within the sickle cell group, such as sickle cell hemoglobin subtype and extent of retinal ischemia. Our findings indicate a factor not yet well known in the pathophysiology of sickle cell disease: an abnormality of local microvascular control.
我们通过计算机辅助测量纯氧呼吸后颞上、下静脉和动脉的收缩情况，对16例镰状细胞病患者和6例对照者的视网膜血管自动调节功能进行了测试。与对照组相比，并校正年龄后，我们发现镰状细胞病组所测的四条血管中有三条血管的血管收缩功能下降，仅颞上动脉的收缩功能下降具有统计学意义（P = 0.009）。患者数量过少，无法对镰状细胞病组内可能的影响因素进行单独分析，如镰状细胞血红蛋白亚型和视网膜缺血程度。我们的研究结果表明了镰状细胞病病理生理学中一个尚未广为人知的因素：局部微血管控制异常。
