血红蛋白SC病和镰状β地中海贫血患儿的脾功能
Splenic function in children with hemoglobin SC disease and sickle beta-thalassemia.
作者信息
Sills R H
出版信息
J Natl Med Assoc. 1983 Oct;75(10):991-4.
Abstract
Splenic function in children with hemoglobin SC disease and sickle β-thalassemia was evaluated using direct interference contrast microscopy. Children with both disorders demonstrated significant degrees of hyposplenism as evidenced by increased numbers of erythrocytes containing surface "pits." Patients with these variants of sickle cell disease frequently exhibit splenic dysfunction and may be at increased risk to develop the life-threatening septicemias associated with hyposplenism.
摘要
采用直接干涉对比显微镜对血红蛋白SC病和镰状β地中海贫血患儿的脾脏功能进行了评估。患有这两种疾病的儿童均表现出明显程度的脾功能减退，含表面“凹坑”的红细胞数量增加证明了这一点。患有这些镰状细胞病变体的患者经常出现脾功能障碍，可能有更高风险发生与脾功能减退相关的危及生命的败血症。
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