Moles Anna, Kieffer Brigitte L, D'Amato Francesca R
Consiglio Nazionale delle Ricerche Institute of Neuroscience, Psychobiology and Psychopharmacology, Viale Marx 43, 00137 Roma, Italy.
Science. 2004 Jun 25;304(5679):1983-6. doi: 10.1126/science.1095943.
Endogenous opioid binding to micro receptors is hypothesized to mediate natural rewards and has been proposed to be the basis of infant attachment behavior. Here, we report that micro-opioid receptor knockout mouse pups emit fewer ultrasonic vocalizations when removed from their mothers but not when exposed to cold or male mice odors. Moreover these knockout pups do not show a preference toward their mothers' cues and do not show ultrasonic calls potentiation after brief maternal exposure. Results from this study may indicate a molecular mechanism for diseases characterized by deficits in attachment behavior, such as autism or reactive attachment disorder.
内源性阿片类物质与微小受体的结合被认为可介导自然奖赏，并且有人提出这是婴儿依恋行为的基础。在此，我们报告微小阿片受体基因敲除的幼鼠在与母亲分离时发出的超声波鸣叫较少，但在暴露于寒冷或雄性小鼠气味时则不然。此外，这些基因敲除的幼鼠对母亲的线索没有表现出偏好，并且在短暂接触母亲后也没有表现出超声波鸣叫增强。这项研究的结果可能表明了一种分子机制，用于解释以依恋行为缺陷为特征的疾病，如自闭症或反应性依恋障碍。
