Lu L, Zhou Z, Wu B, Xiao M, Shen R N, Williams D E, Kim Y J, Kwon B S, Ruscetti S, Broxmeyer H E
Department of Medicine (Hematology/Oncology), Indiana University School of Medicine, Indianapolis 46202-5121.
Int J Cancer. 1992 Sep 9;52(2):261-5. doi: 10.1002/ijc.2910520218.
Recombinant human (rhu) IL-7 was evaluated for its influence on disease progression in mice infected with the polycythemia-inducing strain of the Friend virus complex (FVC). DBA/2 mice were injected i.v. with FVC, and then treated s.c. with rhuIL-7. IL-7 significantly prolonged survival time and decreased spleen focus-forming virus (SFFV) levels, expression of SFFV mRNA and SFFV protein production in FVC-infected mice. IL-7 did not appear to directly inactivate SFFV. Although both splenic weight and cellularity in FVC-infected mice treated with IL-7 were higher than those of normal mice, they were respectively 58% and 66% lower than those of the untreated FVC-infected mice. NK-cell activity was substantially lower in FVC-infected mice than in normal mice, while IL-7 restored NK-cell activity to normal levels. IL-6 and IFN-gamma levels were markedly reduced in FVC-infected mice compared to normal mice, but treatment of FVC-infected mice with IL-7 restored these cytokine levels. While the actual mechanisms of these effects are not yet known, the results suggest the potential therapeutic efficacy of IL-7 for certain hematopoietic and viral disorders, possibly mediated through an action on accessory cells and cytokine production.
对重组人（rhu）白细胞介素-7（IL-7）在感染弗氏病毒复合物（FVC）多血症诱导株的小鼠中对疾病进展的影响进行了评估。给DBA/2小鼠静脉注射FVC，然后皮下注射rhuIL-7。IL-7显著延长了FVC感染小鼠的存活时间，并降低了脾脏集落形成病毒（SFFV）水平、SFFV mRNA表达和SFFV蛋白产生。IL-7似乎并未直接使SFFV失活。虽然用IL-7治疗的FVC感染小鼠的脾脏重量和细胞数量均高于正常小鼠，但分别比未治疗的FVC感染小鼠低58%和66%。FVC感染小鼠的自然杀伤（NK）细胞活性显著低于正常小鼠，而IL-7将NK细胞活性恢复到正常水平。与正常小鼠相比，FVC感染小鼠的IL-6和γ干扰素水平显著降低，但用IL-7治疗FVC感染小鼠可恢复这些细胞因子水平。虽然这些作用的实际机制尚不清楚，但结果表明IL-7对某些造血和病毒性疾病具有潜在的治疗效果，可能是通过对辅助细胞和细胞因子产生的作用介导的。
