McChargue Dennis E, Spring Bonnie, Cook Jessica W, Neumann Christopher A
University of Illinois at Chicago, Chicago, IL, USA.
Addict Behav. 2004 Jul;29(5):991-4. doi: 10.1016/j.addbeh.2004.02.048.
Little is understood about biobehavioral mechanisms that mediate the comorbidity between cigarette smoking and depression. We hypothesized that expectancies about nicotine's reinforcing effects are associated with vulnerability to depression, and may partially explain the relationship between history of depression and smoking. Young adult smokers and never smokers (N=175, mean age=19.9 years, S.D.=3.2) were assessed for history of depression and expectations about the negative (e.g., dispels bad moods) and positive (e.g., increases pleasure) reinforcing effects of smoking. Results are inconsistent with the premise that negative reinforcement expectancies mediate the comorbidity between depression and nicotine dependence. Instead, findings suggest that young adults with a prior history of major depression hold exaggerated expectations about nicotine's positive effects, which could enhance their likelihood of initiating smoking.
对于介导吸烟与抑郁症共病的生物行为机制，人们了解甚少。我们假设，对尼古丁强化作用的预期与抑郁症易感性相关，并且可能部分解释抑郁症病史与吸烟之间的关系。对年轻成年吸烟者和从不吸烟者（N = 175，平均年龄 = 19.9岁，标准差 = 3.2）评估抑郁症病史以及对吸烟的负面（如消除坏心情）和正面（如增加愉悦感）强化作用的预期。结果与负面强化预期介导抑郁症与尼古丁依赖共病这一前提不一致。相反，研究结果表明，有重度抑郁症病史的年轻成年人对尼古丁的积极作用持有夸大的预期，这可能会增加他们开始吸烟的可能性。
