Hviid Thomas Vauvert
Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.
Hum Immunol. 2004 Jun;65(6):586-93. doi: 10.1016/j.humimm.2004.03.002.
The human leukocyte antigen (HLA)-G is expressed by extravillous cytotrophoblast cells in the feto-maternal contact zone. Polymorphisms have been described in the HLA-G gene and have been linked with differences in HLA-G mRNA alternative splicing patterns and protein expression. Differences in the isoform profile or the degree of HLA-G expression may influence cytokine production and, thereby, placental and fetal growth. Associations between a 14 bp deletion polymorphism in the 3'UTR part of the HLA-G gene and birth weight in relation to gestational age and placental weight were studied in 47 pregnancies complicated with preeclampsia and 87 with no preeclampsia. An HLA-G genotype homozygous for the presence of the 14 bp sequence polymorphism was significantly associated with increased birth weight in relation to gestational age (one-way analysis of variance; 2 degrees of freedom: p = 0.02) and with placental weight at birth (>38 weeks of gestation; +14 bp/+14 bp vs others; unpaired t-test: p = 0.03). There was also a slightly higher placental ratio in the offspring with the +14 bp/+14 bp genotype. The implications of these findings are discussed in relation to certain complications of pregnancy and in an evolutionary perspective.
人类白细胞抗原（HLA）-G由母胎接触区的绒毛外细胞滋养层细胞表达。HLA-G基因存在多态性，且与HLA-G mRNA可变剪接模式及蛋白表达的差异有关。同种型谱或HLA-G表达程度的差异可能影响细胞因子的产生，进而影响胎盘和胎儿的生长。在47例合并先兆子痫的妊娠和87例无先兆子痫的妊娠中，研究了HLA-G基因3'UTR部分14 bp缺失多态性与出生体重（相对于孕周）及胎盘重量之间的关联。14 bp序列多态性纯合的HLA-G基因型与相对于孕周的出生体重增加显著相关（单因素方差分析；自由度为2：p = 0.02），且与出生时的胎盘重量相关（妊娠>38周；+14 bp/+14 bp与其他基因型相比；非配对t检验：p = 0.03）。+14 bp/+14 bp基因型后代的胎盘比率也略高。本文从妊娠的某些并发症及进化角度对这些发现的意义进行了讨论。
