A convenient method for regional monoamine oxidase-A determination by [14C]clorgyline autoradiography.
作者信息
Murakami M, Kondoh Y, Weimin Y, Mizusawa S, Nakamichi H, Takahashi K, Sasaki H, Iida H, Miura S, Kanno I
机构信息
Department of Radiology, Research Institute for Brain and Blood Vessels-Akita, Japan.
出版信息
Int J Rad Appl Instrum B. 1992 Aug;19(6):619-26. doi: 10.1016/0883-2897(92)90096-h.
The availability of clorgyline for regional monoamine oxidase-A (MAO-A) determination was examined using [14C]clorgyline in rat. [14C]Clorgyline was synthesized by the methylation reaction of N-desmethyl-clorgyline and [14C]methyliodide in dimethylformamide with high radiochemical yield. The MAO-A distribution map by autoradiography correlated with that by histochemical technique and its quantity was consistent with the calculated MAO-A amount based on previous reports. The combination of labeled clorgyline and autoradiographic technique will promise the quantitative measurement of regional MAO-A distribution.
Zotero 插件