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On-line radiochemical assay for monoamine oxidase utilizing high-performance liquid chromatography.

作者信息

Nissinen E, Linko-Löppönen S, Männistö P

出版信息

J Pharmacol Methods. 1984 Dec;12(4):247-54. doi: 10.1016/0160-5402(84)90010-x.

DOI:10.1016/0160-5402(84)90010-x
PMID:6443138
Abstract

A fast and sensitive assay for the determination of monoamine oxidase activity was developed. The method is based on the separation and quantitation of 14C-labeled assay products by high-performance liquid chromatography, which is interfaced directly into a flow-through radioactivity detector. This allows on-line quantitation of the radioactive compounds with picomole sensitivity. The method makes possible the complete separation and detection of the deaminated products of monoamine oxidase A and B substrates benzylamine and 5-hydroxytryptamine, respectively. This assay has been applied to the measurement of monoamine oxidase A and B activities in rat brain.

摘要

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