Schwendner S W, Weichert J P, Longino M A, Gross M D, Counsell R E
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109.
Int J Rad Appl Instrum B. 1992 Aug;19(6):639-50. doi: 10.1016/0883-2897(92)90098-j.
A triglyceride analog, glycerol-2-palmitoyl-1,3-di-15-(p-iodophenyl)pentadecanoate (DPPG) was synthesized and radiolabeled for evaluation as a potential functional liver scintigraphic agent. Uptake of DPPG was compared in normal, diabetic, tumor-bearing and heparin pretreated rats, revealing differences in uptake and clearance of radioactivity, correlating with hepatic lipase activity of these groups. Similar results were observed by gamma-camera scintigraphy. Comparing the uptake of DPPG with that of its fatty acid component, 15-(p-iodophenyl)pentadecanoic acid (IPPA), revealed that the peak uptake of IPPA in the liver was about half that of DPPG. Based upon these findings, DPPG warrants further study as a hepatic radiodiagnostic agent.
合成了一种甘油三酯类似物，即甘油-2-棕榈酰基-1,3-二-15-（对碘苯基）十五烷酸酯（DPPG），并对其进行放射性标记，以评估其作为潜在功能性肝脏闪烁显像剂的性能。比较了正常、糖尿病、荷瘤和肝素预处理大鼠对DPPG的摄取情况，发现放射性摄取和清除存在差异，这与这些组的肝脂肪酶活性相关。γ相机闪烁显像也观察到了类似结果。将DPPG与其脂肪酸成分15-（对碘苯基）十五烷酸（IPPA）的摄取情况进行比较，发现IPPA在肝脏中的摄取峰值约为DPPG的一半。基于这些发现，DPPG作为肝脏放射性诊断剂值得进一步研究。
