慢病毒转导树突状细胞可在体内赋予保护性抗病毒免疫力。
Lentiviral transduction of dendritic cells confers protective antiviral immunity in vivo.
作者信息
Zarei Shohreh, Abraham Shahnaz, Arrighi Jean-Francois, Haller Olivier, Calzascia Thomas, Walker Paul R, Kündig Thomas M, Hauser Conrad, Piguet Vincent
机构信息
Department of Immunology and Allergy, University Hospital of Geneva, Geneva, Switzerland.
出版信息
J Virol. 2004 Jul;78(14):7843-5. doi: 10.1128/JVI.78.14.7843-7845.2004.
Abstract
Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.
摘要
体内病毒感染的控制需要快速且高效的细胞毒性T淋巴细胞反应。我们证明，在淋巴细胞性脉络丛脑膜炎病毒模型中，慢病毒介导的抗原导入树突状细胞可在体内赋予保护性抗病毒免疫。因此，慢病毒载体可能是病毒感染的优秀疫苗候选物。
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