Chiewchanvit Siri, Noppakun Khajornsakdi, Kanchanarattanakorn Kittika
Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Thailand.
J Med Assoc Thai. 2004 May;87(5):508-14.
There have been many reports about mucocutaneous complications of chemotherapy from western countries, but they are only small case series. Until now, there had been no such report in Thailand.
We assessed mucocutaneous complications in patients who received chemotherapy.
A total of 74 patients, admitted for chemotherapy from October 2001 to January 2002 in the Internal Medicine Department, Maharaj Nakhon Chiang Mai Hospital, were studied.
Of 74 patients (53 male and 21 female), we found a statistically significant relation between gemcitabine and alopecia (p = .020), bleomycin and hyperpigmentation (p = .030), and cytarabine and ichthyosis (< .001). The most common findings were alopecia (76.68%), hyperpigmentation (31.08%), transverse white bands of the nails (22.97%), and ichthyosis (20.27%). Other notable findings included oral mucositis, acne, acral erythema, flushing, onycholysis, urticaria, pruritus, phlebitis and cutaneous infections (including tinea corporis, tinea ungium, and warts).
Mucocutaneous complications are common in patients who have received chemotherapy. However, a further study with a larger sample size and specified chemotherapy regimen would be valuable.
西方国家有许多关于化疗引起的皮肤黏膜并发症的报道，但都只是小样本病例系列。到目前为止，泰国尚无此类报道。
我们评估了接受化疗患者的皮肤黏膜并发症。
对2001年10月至2002年1月在清迈玛哈叻那空医院内科住院接受化疗的74例患者进行了研究。
在74例患者（53例男性和21例女性）中，我们发现吉西他滨与脱发之间存在统计学显著相关性（p = 0.020），博来霉素与色素沉着之间存在相关性（p = 0.030），阿糖胞苷与鱼鳞病之间存在相关性（p < 0.001）。最常见的表现为脱发（76.68%）、色素沉着（31.08%）、指甲横纹（22.97%）和鱼鳞病（20.27%）。其他值得注意的表现包括口腔黏膜炎、痤疮、肢端红斑、潮红、甲剥离、荨麻疹、瘙痒、静脉炎和皮肤感染（包括体癣、甲癣和疣）。
皮肤黏膜并发症在接受化疗的患者中很常见。然而，进一步开展更大样本量和特定化疗方案的研究将很有价值。
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