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一项分析化疗所致脱发及其对成人心理社会影响的描述性研究:来自一家三级护理医院的经验

A Descriptive Study to Analyze Chemotherapy-Induced Hair Loss and its Psychosocial Impact in Adults: Our Experience from a Tertiary Care Hospital.

作者信息

Saraswat Neerja, Chopra Ajay, Sood Aradhana, Kamboj Parul, Kumar Sushil

机构信息

Department of Dermatology, Base Hospital, Delhi Cantt, Delhi, India.

Department of Dermatology, Base Hospital, Lucknow Cantt, Uttar Pradesh, India.

出版信息

Indian Dermatol Online J. 2019 Jul-Aug;10(4):426-430. doi: 10.4103/idoj.IDOJ_471_18.

Abstract

BACKGROUND

Hair loss is one of the most commonly reported and psychologically distressing adverse effects of chemotherapeutic agents. Studies on its impact on psychosocial aspect of cancer patients are lacking at present.

OBJECTIVE

To study the chemotherapeutic agents causing hair loss and its psychosocial implications in adults.

MATERIALS AND METHODS

Observational study was done for a period of 1 year, wherein all cancer patients, more than 18 years of age who developed hair loss while on chemotherapy were assessed for type of malignancy, details of chemotherapy protocol, their knowledge about chemotherapeutic agents induced hair loss, and its impact on their social life and patterns of adjustment to deal with it. A prevalidated closed-ended questionnaire was used as a data collection tool.

RESULTS

Out of 179 patients, 96 (53.6%) were males as against 80 (44.6%) females, and 49 (27.3%) patients were between 18 and 30 years of age. Carcinoma lung was the most common malignancy seen in 46 (25.6%) patients followed by rectosigmoid carcinoma in 41 (22.9%) patients. Combination of cyclophosphamide and doxorubicin was the most common combination resulting in hair loss in 49 (27.3%) cancer patients. A total of 101 (56.4%) patients felt that hair loss was the worst side effect of chemotherapy, while 29 (16.2%) had to continue because it was life-saving. A total of 129 (72%) patients said hair loss is affecting their social life; 37 (20.6%) patients were using hair accessories while 69 (38.5%) did not even attempt to hide hair loss as they were too occupied with fear of disease.

CONCLUSION

Chemotherapy-induced hair loss is a common adverse effect in cancer patients undergoing treatment. A thorough counseling about it and methods to deal with it should be a part of management of the patients.

摘要

背景

脱发是化疗药物最常报告且在心理上令人苦恼的不良反应之一。目前缺乏关于其对癌症患者心理社会层面影响的研究。

目的

研究导致成年人脱发的化疗药物及其心理社会影响。

材料与方法

进行为期1年的观察性研究,评估所有18岁以上在化疗期间出现脱发的癌症患者的恶性肿瘤类型、化疗方案细节、他们对化疗药物所致脱发的了解情况,以及脱发对其社交生活的影响和应对脱发的调整方式。使用预先验证的封闭式问卷作为数据收集工具。

结果

179例患者中,男性96例(53.6%),女性80例(44.6%),49例(27.3%)患者年龄在18至30岁之间。肺癌是最常见的恶性肿瘤,46例(25.6%)患者患有肺癌,其次是直肠乙状结肠癌,41例(22.9%)患者患有该疾病。环磷酰胺和阿霉素联合使用是导致脱发最常见的组合,49例(27.3%)癌症患者出现脱发。共有101例(56.4%)患者认为脱发是化疗最严重的副作用,而29例(16.2%)患者因化疗能挽救生命而不得不继续。共有129例(72%)患者表示脱发影响了他们的社交生活;37例(20.6%)患者使用头发配饰,而69例(38.5%)患者甚至没有试图掩盖脱发,因为他们过于担心疾病。

结论

化疗引起的脱发是接受治疗的癌症患者常见的不良反应。对此进行全面的咨询以及应对方法应成为患者治疗管理的一部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/6615375/cf74d24b7b4f/IDOJ-10-426-g001.jpg

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