Malhotra R, Singh J P, Dudeja M, Dhindsa K S
Department of Chemistry and Biochemistry, Haryana Agricultural University, Hisar, India.
J Inorg Biochem. 1992 May 1;46(2):119-27. doi: 10.1016/0162-0134(92)80015-n.
New complexes of Cu(II), Ni(II), and Co(II) with 3-benzoyl-1-[2-N-(substituted-2'-thienyl methylmethylene/methylene)] prop-2-ene-1-oic acid hydrazides have been synthesized and characterized by elemental analysis, molecular weight determination, molar conductance, and magnetic moment and spectroscopic techniques. Conductance measurements indicate the nonionic nature of the complexes. From the spectroscopic studies, it has been concluded that the N-substituted acid hydrazides act as tridentate ligands forming an O-N-S conjugate system and coordinating with metal ions through oxygen of carbonyl group, nitrogen of azomethine, and sulphur of thiophene moiety. Octahedral geometry has been proposed for all the complexes. The ligands and their complexes were tested for in vitro growth inhibitory activity against phytopathogenic fungi viz. Alternaria alternata, Colletotrichum capsicum, Fusarium oxysporum, and Rhizoctonia solani at 28 degrees C; and bacteria viz. gram positive Bacillus subtilis and gram negative Escherichia coli at 37 degrees C by a two-fold serial dilution technique. In some cases an increase in the biocidal activity of the ligands as a consequence of coordination with metal ions was observed in terms of minimum inhibitory concentration (MIC) values. The trend of growth inhibition in the complexes was found to be in the order: Cu greater than Ni greater than Co.
已合成了铜（II）、镍（II）和钴（II）与3-苯甲酰基-1-[2-N-（取代-2'-噻吩基亚甲基/亚甲基）]丙-2-烯-1-酸酰肼形成的新型配合物，并通过元素分析、分子量测定、摩尔电导率、磁矩和光谱技术对其进行了表征。电导率测量表明配合物具有非离子性质。通过光谱研究得出结论，N-取代的酰肼作为三齿配体，形成O-N-S共轭体系，并通过羰基的氧、偶氮甲碱的氮和噻吩部分的硫与金属离子配位。已为所有配合物提出了八面体几何结构。测试了配体及其配合物对植物致病真菌的体外生长抑制活性，即28℃下的链格孢、辣椒炭疽菌、尖孢镰刀菌和立枯丝核菌；以及37℃下的细菌，即革兰氏阳性枯草芽孢杆菌和革兰氏阴性大肠杆菌，采用两倍系列稀释技术。在某些情况下，从最低抑菌浓度（MIC）值来看，观察到配体与金属离子配位后杀菌活性有所增加。发现配合物中生长抑制的趋势为：铜＞镍＞钴。
