Malhotra R, Malik M S, Singh J P, Dhindsa K S
Department of Chemistry and Biochemistry, Haryana Agricultural University, Hisar, India.
J Inorg Biochem. 1992 Mar;45(4):269-75. doi: 10.1016/0162-0134(92)84015-f.
Complexes of alpha-methyl-(2-thiophenomethylene) aryloxyacetic acid hydrazides with Cu(II) and Zn(II) metal salts were synthesized and characterized by elemental analysis, molecular weight determination, molar conductance, and magnetic moment and spectroscopic techniques. In these complexes, the ligands form a conjugate O-N-S tridenate system, thus coordinating with metal through oxygen of the carbonyl group, nitrogen of azomethine, and sulphur of thiophenemoiety. Octahedral geometry is proposed for all the complexes. Antifungal activity of the ligands and their Cu(II) and Zn(II) complexes was determined against plant pathogenic fungi viz. Alternaria alternata, Rhizoctonia solani, Colletotrichum capsicum, and Glomeralla cingulata at 28 degrees C. Antibacterial activity of ligands and their metal complexes was determined on gram positive Bacillus subtilis and gram negative Escherichia coli bacteria at 37 degrees C by the serial dilution method. In some cases an increase in biocidal activity of the ligands on coordination with metal ions was observed in terms of minimum inhibitory concentration (MIC) values.
合成了α-甲基-(2-噻吩基亚甲基)芳氧基乙酸酰肼与铜(II)和锌(II)金属盐的配合物，并通过元素分析、分子量测定、摩尔电导率、磁矩和光谱技术对其进行了表征。在这些配合物中，配体形成共轭的O-N-S三齿体系，从而通过羰基的氧、偶氮甲碱的氮和噻吩部分的硫与金属配位。所有配合物均提出为八面体几何构型。测定了配体及其铜(II)和锌(II)配合物对植物病原真菌即链格孢、立枯丝核菌、辣椒炭疽菌和围小丛壳菌在28℃下的抗真菌活性。通过系列稀释法在37℃下测定了配体及其金属配合物对革兰氏阳性枯草芽孢杆菌和革兰氏阴性大肠杆菌的抗菌活性。在某些情况下，根据最低抑菌浓度(MIC)值观察到配体与金属离子配位后杀菌活性增加。
