Fijnvandraat A C, Moorman A F
Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Anatomie en Embryologie, Meibergdreef 15, 1105 AZ Amsterdam.
Ned Tijdschr Geneeskd. 2004 Jun 12;148(24):1186-91.
If the heart fails to recover sufficient functionality following an infarct, then heart failure develops, an important cause of death in the western world. One obvious therapy is to create more muscle tissue to supplement the damaged myocardium with new functional contractile cells, together with neovasculogenesis. Stem cells repair recipient tissue by differentiating into tissue-specific cells or by creating an environment that stimulates the process of repair by the body's own cells at the site. In animal studies the heart function stabilised following an injection of stem cells in the infarcted area. In 3 non-randomised trials in humans, bone marrow stem cells were injected via the infarcted artery or round the infarcted area; the results indicated an improved heart function. There is currently still insufficient fundamental knowledge about the behaviour of multipotent cells, about the effects of using them for treatment, and about their long-term risk for these cells to be employed in the treatment of patients with a heart infarct.
如果心脏在梗死之后无法恢复足够的功能，那么就会发展为心力衰竭，这是西方世界一个重要的死亡原因。一种显而易见的治疗方法是生成更多的肌肉组织，用新的功能性收缩细胞补充受损的心肌，同时促进新生血管形成。干细胞通过分化为组织特异性细胞或通过营造一种环境来修复受体组织，这种环境能刺激身体自身细胞在该部位进行修复过程。在动物研究中，在梗死区域注射干细胞后心脏功能趋于稳定。在三项针对人类的非随机试验中，通过梗死动脉或在梗死区域周围注射骨髓干细胞；结果显示心脏功能有所改善。目前，对于多能细胞的行为、使用它们进行治疗的效果以及将这些细胞用于治疗心肌梗死患者的长期风险，仍然缺乏足够的基础知识。
