Slootweg P J
Divisie Laboratoria en Apotheek, afdeling Pathologie, van het Universitair Medisch Centrum, Utrecht.
Ned Tijdschr Tandheelkd. 2004 Jun;111(6):226-9.
Processes playing a role in normal odontogenesis may also occur in development of odontogenic tumours. Studying odontogenesis may shed new light on the pathogenesis of odontogenic tumours and studying odontogenic tumours may do the same for understanding normal odontogenesis. An overview is given on the developments in this field since the last 25 years. Analysis of protein and gene expression have deepened the understanding of mechanisms playing a role in odontogenesis but thus far has not contributed very much to the knowledge on the pathogenesis of odontogenic tumours.
在正常牙胚发生过程中发挥作用的过程也可能发生在牙源性肿瘤的发展中。研究牙胚发生可能为牙源性肿瘤的发病机制提供新的线索，而研究牙源性肿瘤也可能对理解正常牙胚发生有同样的作用。本文对过去25年该领域的进展进行了综述。蛋白质和基因表达分析加深了对牙胚发生机制的理解，但迄今为止对牙源性肿瘤发病机制的认识贡献不大。
