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J Clin Invest. 2003 Nov;112(10):1571-80. doi: 10.1172/JCI18986.
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Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease.白细胞介素15：乳糜泻中上皮内淋巴细胞稳态破坏和淋巴瘤发生的关键因素。
Gastroenterology. 2003 Sep;125(3):730-45. doi: 10.1016/s0016-5085(03)01047-3.
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IL-15 is elevated in sera of patients with relapsing-remitting multiple sclerosis.
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Cytokines and autoimmunity.细胞因子与自身免疫
Nat Rev Immunol. 2002 Jan;2(1):37-45. doi: 10.1038/nri702.
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IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients.白细胞介素-15在HAM/TSP患者中针对Tax的特异性CD8细胞的持续存在中起主要作用。
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Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy.白细胞介素-2和白细胞介素-15在淋巴细胞生死过程中的对比作用：对免疫治疗的启示
Immunity. 2001 Feb;14(2):105-10.
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IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice.在白细胞介素-15转基因小鼠中，白细胞介素-2诱导的活化诱导细胞死亡受到抑制。
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Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis.类风湿关节炎患者成纤维样滑膜细胞白细胞介素-7和白细胞介素-15的产生
Arthritis Rheum. 1999 Jul;42(7):1508-16. doi: 10.1002/1529-0131(199907)42:7<1508::AID-ANR26>3.0.CO;2-L.
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IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation.白细胞介素-15受体通过支持淋巴细胞归巢和增殖来维持淋巴内环境稳定。
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针对炎症性自身免疫性疾病中的白细胞介素-15/白细胞介素-15受体系统

Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases.

作者信息

Waldmann Thomas A

机构信息

Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Arthritis Res Ther. 2004;6(4):174-7. doi: 10.1186/ar1202. Epub 2004 Jun 22.

DOI:10.1186/ar1202
PMID:15225362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC464917/
Abstract

Interleukin (IL)-15 is a dangerous inflammatory cytokine that induces tumor-necrosis factor-alpha, IL-1beta and inflammatory chemokines. It inhibits self-tolerance mediated by IL-2 mediated activation-induced cell death and facilitates maintenance of CD8+ memory T-cell survival including that of self-directed memory cells. Disordered IL-15 expression has been reported in patients with an array of inflammatory autoimmune diseases. A series of therapeutic agents that inhibit IL-15 action have been introduced, including the soluble IL-15 receptor (IL-15R) alpha chain, mutant IL-15, and antibodies directed against the IL-15 cytokine and against the IL-2R/IL-15R beta subunit used by IL-2 and IL-15.

摘要

白细胞介素（IL）-15是一种危险的炎性细胞因子，可诱导肿瘤坏死因子-α、IL-1β和炎性趋化因子。它抑制由IL-2介导的活化诱导细胞死亡所介导的自身耐受性，并促进CD8+记忆T细胞存活的维持，包括自身导向记忆细胞的存活。据报道，一系列炎性自身免疫性疾病患者存在IL-15表达紊乱的情况。已经引入了一系列抑制IL-15作用的治疗药物，包括可溶性IL-15受体（IL-15R）α链、突变型IL-15，以及针对IL-15细胞因子和针对IL-2和IL-15所使用的IL-2R/IL-15Rβ亚基的抗体。