mRNA 降解的调控：脱帽独立进行。
Regulation of mRNA decay: decapping goes solo.
作者信息
Jacobson Allan
机构信息
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
出版信息
Mol Cell. 2004 Jul 2;15(1):1-2. doi: 10.1016/j.molcel.2004.06.031.
PMID:15225542
Abstract
In this issue of Molecular Cell, Badis et al. demonstrate that autoregulated destabilization of the RPS28B mRNA is mediated by Edc3p interaction with an Rps28p/3'UTR mRNP complex. Subsequent recruitment of Dcp1p/Dcp2p to the complex appears to ensure rapid, deadenylation-independent decapping of the mRNA.
摘要
在本期《分子细胞》杂志中，巴迪斯等人证明，RPS28B信使核糖核酸（mRNA）的自动调节性去稳定作用是由Edc3p与Rps28p/3'非翻译区（UTR）信使核糖核蛋白（mRNP）复合物的相互作用介导的。随后，Dcp1p/Dcp2p被招募到该复合物中，这似乎确保了mRNA的快速、不依赖于去腺苷酸化的脱帽过程。
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