Novotney C A, Page R L, Macy D W, Dewhirst M W, Ogilvie G K, Withrow S J, McEntee M C, Heidner G L, Allen S A, Thrall D E
College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
J Vet Intern Med. 1992 Jul-Aug;6(4):245-9. doi: 10.1111/j.1939-1676.1992.tb00346.x.
Fifteen previously untreated dogs with histologically confirmed, high-grade multicentric lymphoma were entered into a phase I study to evaluate combined doxorubicin and whole-body hyperthermia (DOX/WBH). Groups of three, four, and eight dogs were treated with whole-body hyperthermia and concurrent doxorubicin at 12 mg/m2, 24 mg/m2 and 30 mg/m2, respectively, after one doxorubicin induction dose at 30 mg/m2. Plateau temperature (42 +/- 0.1 degree C) was maintained for 90 minutes using a radiant heating device. A total of five DOX/WBH treatments per dog were planned, and these were given every 21 days. Treatment-related toxicity was not seen in the 12-mg/m2 doxorubicin dose group. Tumor progression prohibited administration of more than three DOX/WBH treatments to any dog in the 12-mg/m2 group. Premature ventricular contractions developed after the fifth treatment in one of the four dogs treated with 24 mg/m2 of doxorubicin. Two dogs (25%) in the 30-mg/m2 dose group had treatment-related toxicity. One dog experienced acute serious myelosuppression 1 week after the third treatment. This dog received all planned DOX/WBH treatments. Asymptomatic cardiac toxicosis consisting of decreased ejection fraction and fractional shortening developed in the second dog. This dog received only two DOX/WBH treatments. The three dogs treated at 12 mg/m2 had partial responses of short duration (60-83 days). Four dogs treated at 24 mg/m2 had complete responses for 150, 164, 186, and 200 days. Eight dogs treated at 30 mg/m2 had complete responses with a mean and median duration of 241 and 190 days, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
15只组织学确诊为高级别多中心淋巴瘤且未经治疗的犬进入一项I期研究，以评估阿霉素与全身热疗联合治疗（DOX/WBH）的效果。在给予30mg/m²阿霉素诱导剂量后，将犬分为三组，每组分别为3只、4只和8只，分别接受全身热疗并同时给予12mg/m²、24mg/m²和30mg/m²的阿霉素。使用辐射加热装置将平台温度维持在（42±0.1℃）90分钟。每只犬计划总共进行5次DOX/WBH治疗，每21天进行一次。在12mg/m²阿霉素剂量组未观察到与治疗相关的毒性。在12mg/m²组中，肿瘤进展导致任何一只犬接受的DOX/WBH治疗不超过3次。接受24mg/m²阿霉素治疗的4只犬中有1只在第5次治疗后出现室性早搏。30mg/m²剂量组中有2只犬（25%）出现与治疗相关的毒性。1只犬在第3次治疗后1周出现急性严重骨髓抑制。这只犬接受了所有计划的DOX/WBH治疗。第二只犬出现无症状心脏中毒，表现为射血分数和缩短分数降低。这只犬仅接受了2次DOX/WBH治疗。接受12mg/m²治疗的3只犬有短期部分缓解（60 - 83天）。接受24mg/m²治疗的4只犬有完全缓解，持续时间分别为150、164、186和200天。接受30mg/m²治疗的8只犬有完全缓解，平均持续时间和中位持续时间分别为241天和190天。（摘要截断于250字）
