• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

三种南美抗蛇毒血清针对五种具有医学重要性的秘鲁蛇毒的临床前测试。

Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms.

作者信息

Laing G D, Yarleque A, Marcelo A, Rodriguez E, Warrell D A, Theakston R D G

机构信息

Alistair Reid Venom Research unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA UK.

出版信息

Toxicon. 2004 Jul;44(1):103-6. doi: 10.1016/j.toxicon.2004.03.020.

DOI:10.1016/j.toxicon.2004.03.020
PMID:15225568
Abstract

World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.

摘要

开展了世界卫生组织（WHO）推荐的临床前体内和体外研究，以比较巴西、秘鲁和哥伦比亚抗蛇毒血清在中和秘鲁五种具有重要医学意义的蛇毒中导致致死、出血、坏死、凝血和去纤维蛋白作用的毒素方面的功效。总体而言，发现巴西抗蛇毒血清最为有效，其次是秘鲁和哥伦比亚抗蛇毒血清。然而，得出的结论是，所有这三种抗蛇毒血清都可用于秘鲁中毒患者的随机临床试验。

相似文献

1
Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms.三种南美抗蛇毒血清针对五种具有医学重要性的秘鲁蛇毒的临床前测试。
Toxicon. 2004 Jul;44(1):103-6. doi: 10.1016/j.toxicon.2004.03.020.
2
Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa.抗蛇毒血清（EchiTAb-Plus-ICP）治疗撒哈拉以南非洲地区蛇咬伤的临床前疗效评估。
Toxicon. 2010 Feb-Mar;55(2-3):369-74. doi: 10.1016/j.toxicon.2009.08.010. Epub 2009 Aug 21.
3
Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment.秘鲁和哥斯达黎加生产的多价抗蛇毒血清对四种秘鲁矛头蝮蛇毒的中和作用：临床前评估
Acta Trop. 2005 Jan;93(1):85-95. doi: 10.1016/j.actatropica.2004.09.008.
4
Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms.抗蛇毒血清组学与六种拉丁美洲抗蛇毒血清对产自哥伦比亚西南部的矛头蝮属asper 种系蛇毒的体内临床前疗效评价。
PLoS Negl Trop Dis. 2021 Feb 1;15(2):e0009073. doi: 10.1371/journal.pntd.0009073. eCollection 2021 Feb.
5
Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms.对 6 个拉丁美洲国家生产的抗蛇毒血清针对具有医学相关性的矛头蝮蛇蛇毒的中和能力进行临床前评估。
Toxicon. 2010 Nov;56(6):980-9. doi: 10.1016/j.toxicon.2010.07.001. Epub 2010 Jul 16.
6
Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays.针对 Cerrophidion sasai、Porthidium nasutum 和 Porthidium ophryomegas 毒液的多特异性抗蛇毒血清的临床前评估：结合抗蛇毒组学和中和测定的见解。
Toxicon. 2013 Mar 15;64:60-9. doi: 10.1016/j.toxicon.2012.12.024. Epub 2013 Jan 10.
7
Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms.厄瓜多尔亚马逊地区的响尾蛇咬伤：三种南美多价抗蛇毒血清的随机双盲对比试验
BMJ. 2004 Nov 13;329(7475):1129. doi: 10.1136/bmj.329.7475.1129.
8
[Biological and immunological characteristics of the poison of Bothrops cotiara (Serpentes: Viperidae)].[科蒂拉矛头蝮（蛇亚目：蝰蛇科）毒液的生物学和免疫学特性]
Rev Biol Trop. 2006 Sep;54(3):889-901.
9
Antivenomics and venom phenotyping: A marriage of convenience to address the performance and range of clinical use of antivenoms.抗蛇毒血清组学和毒液表型分析：一种便利的结合，旨在解决抗蛇毒血清的性能和临床应用范围。
Toxicon. 2010 Dec 15;56(7):1284-91. doi: 10.1016/j.toxicon.2009.12.015. Epub 2009 Dec 29.
10
Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico.墨西哥生产的一种多特异性抗蛇毒血清对医学相关的矛头蝮属（有鳞目：蝰蛇科）蛇毒毒性作用的临床前疗效。
Rev Biol Trop. 2017 Mar;65(1):345-50. doi: 10.15517/rbt.v65i1.18908.

引用本文的文献

1
Immunorecognition and Neutralization of Venom by a Commercial Antivenom Produced in Colombia.免疫识别与中和毒液的商业抗毒液生产在哥伦比亚。
Toxins (Basel). 2022 Mar 25;14(4):235. doi: 10.3390/toxins14040235.
2
Comparative characterization of Viperidae snake venoms from Perú reveals two compositional patterns of phospholipase A expression.秘鲁蝰蛇科蛇毒的比较特征揭示了磷脂酶A表达的两种组成模式。
Toxicon X. 2020 May 30;7:100044. doi: 10.1016/j.toxcx.2020.100044. eCollection 2020 Sep.
3
Venomics and antivenomics of the poorly studied Brazil's lancehead, (Hoge, 1954), from the Brazilian State of Pará.
对来自巴西帕拉州、研究较少的巴西矛头蝮（霍格，1954年）的毒液组学和抗毒液组学研究
J Venom Anim Toxins Incl Trop Dis. 2020 Apr 17;26:e20190103. doi: 10.1590/1678-9199-JVATITD-2019-0103. eCollection 2020.
4
Safety and efficacy of a freeze-dried trivalent antivenom for snakebites in the Brazilian Amazon: An open randomized controlled phase IIb clinical trial.冻干三价抗蛇毒血清用于巴西亚马逊地区蛇咬伤的安全性和有效性：一项开放随机对照IIb期临床试验。
PLoS Negl Trop Dis. 2017 Nov 27;11(11):e0006068. doi: 10.1371/journal.pntd.0006068. eCollection 2017 Nov.
5
Diagnosis of snakebite and the importance of immunological tests in venom research.蛇伤诊断及免疫检测在蛇毒研究中的重要性。
Toxins (Basel). 2014 May 23;6(5):1667-95. doi: 10.3390/toxins6051667.
6
Use of a synthetic biosensor for neutralizing activity-biased selection of monoclonal antibodies against atroxlysin-I, an hemorrhagic metalloproteinase from Bothrops atrox snake venom.利用合成生物传感器中和抗atroxlysin-I 的单克隆抗体的活性偏倚选择，atroxlysin-I 是来自矛头蝮蛇（Bothrops atrox）蛇毒的一种出血金属蛋白酶。
PLoS Negl Trop Dis. 2014 Apr 24;8(4):e2826. doi: 10.1371/journal.pntd.0002826. eCollection 2014 Apr.