Kinnula Vuokko L, Pääkkö Paavo, Soini Ylermi
Department of Medicine, Division of Pulmonary Diseases, University of Helsinki and Helsinki University Hospital, P.O. Box 22 (Haartmaninkatu 4), 00014 Helsinki, Finland.
FEBS Lett. 2004 Jul 2;569(1-3):1-6. doi: 10.1016/j.febslet.2004.05.045.
Oxidants are known to modulate cell proliferation and apoptosis, and induce synthesis of growth factors that play an important role in tumor growth and invasion. Antioxidant enzymes and thiol proteins regulating cellular redox state constitute the major cellular protection against oxidants. Consequently, they are also associated both with carcinogenesis and tumor progression. Superoxide dismutases, glutamate cysteine ligase, catalase, thioredoxins and peroxiredoxins, which are the most important of these enzymes, are expressed in lung malignancies, and especially in pleural mesothelioma. This has consequences not only for tumor behavior but also for resistance of tumor cells to cytotoxic drugs and radiation.
已知氧化剂可调节细胞增殖和凋亡，并诱导生长因子的合成，而这些生长因子在肿瘤生长和侵袭中发挥着重要作用。调节细胞氧化还原状态的抗氧化酶和硫醇蛋白构成了细胞对抗氧化剂的主要保护机制。因此，它们也与致癌作用和肿瘤进展相关。超氧化物歧化酶、谷氨酸半胱氨酸连接酶、过氧化氢酶、硫氧还蛋白和过氧化物还原酶是这些酶中最重要的几种，它们在肺恶性肿瘤中表达，尤其是在胸膜间皮瘤中。这不仅对肿瘤行为有影响，而且对肿瘤细胞对细胞毒性药物和辐射的抗性也有影响。
