氟西汀和舍曲林通过迷走神经途径刺激麻醉大鼠的胃酸分泌。
Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats.
作者信息
Abdel Salam Omar M E
机构信息
Department of Pharmacology, National Research Centre, Tahrir St., Dokki, Cairo, Egypt.
出版信息
Pharmacol Res. 2004 Sep;50(3):309-16. doi: 10.1016/j.phrs.2004.01.010.
The effect of the selective serotonin reuptake inhibitors, fluoxetine and sertraline on basal, secretagogues (histamine or bethanechol)- and distention-stimulated gastric acid secretion was investigated in the urethane-anaesthetised acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric contents with saline every 15 min. Fluoxetine (10 or 20 mg kg(-1), i.p.) produced a dose-dependent increase in basal gastric acid secretion. These stimulatory effects were abolished by vagotomy. Intraperitoneally administered sertraline also stimulated gastric acid secretion. The stimulatory effect of lower doses (5 mg kg(-1)) of sertraline was similar to that of the higher (30 mg kg(-1)) doses. The gastric secretory response to i.p. sertraline was long lasting (greater than 60 min), and blocked by vagotomy. Intraperitoneally administered fluoxetine (10 or 20 mg kg(-1)) or sertraline (5 mg kg(-1)) also increased gastric secretion induced by histamine, bethanechol or distention. The fluoxetine or sertraline stimulatory effects of histamine-induced acid secretion were abolished by vagotomy. Data indicate a stimulatory effect for fluoxetine and sertraline mediated by vagal nerve on gastric acid secretion in urethane-anaesthetised rats.
在氨基甲酸乙酯麻醉的急性胃瘘大鼠中，研究了选择性5-羟色胺再摄取抑制剂氟西汀和舍曲林对基础胃酸分泌、促分泌剂（组胺或氨甲酰甲胆碱）刺激的胃酸分泌以及扩张刺激的胃酸分泌的影响。每隔15分钟用生理盐水冲洗胃内容物来测量胃酸分泌。氟西汀（10或20mg/kg，腹腔注射）使基础胃酸分泌呈剂量依赖性增加。这些刺激作用在迷走神经切断后被消除。腹腔注射舍曲林也刺激胃酸分泌。较低剂量（5mg/kg）舍曲林的刺激作用与较高剂量（30mg/kg）相似。腹腔注射舍曲林引起的胃分泌反应持续时间长（大于60分钟），并被迷走神经切断所阻断。腹腔注射氟西汀（10或20mg/kg）或舍曲林（5mg/kg）也增加组胺、氨甲酰甲胆碱或扩张诱导的胃分泌。迷走神经切断消除了氟西汀或舍曲林对组胺诱导的胃酸分泌的刺激作用。数据表明，在氨基甲酸乙酯麻醉的大鼠中，氟西汀和舍曲林通过迷走神经对胃酸分泌起刺激作用。
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