雌激素受体配体。第7部分：带有双环胺侧链的二氢苯并噻吩类选择性雌激素受体调节剂
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.
作者信息
Blizzard Timothy A, DiNinno Frank, Morgan Jerry D, Chen Helen Y, Wu Jane Y, Gude Candido, Kim Seongkon, Chan Wanda, Birzin Elizabeth T, Tien Yang Yi, Pai Lee-Yuh, Zhang Zhoupeng, Hayes Edward C, DaSilva Carolyn A, Tang Wei, Rohrer Susan P, Schaeffer James M, Hammond Milton L
机构信息
Merck Research Laboratories, Medicinal Chemistry, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 2004 Aug 2;14(15):3861-4. doi: 10.1016/j.bmcl.2004.05.074.
PMID:15225685
Abstract
A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.
摘要
制备了一系列带有双环胺侧链的苯并噻二嗪类选择性雌激素受体调节剂（SERAMs）。侧链的微小修饰对生物活性产生了显著影响，尤其是对子宫组织的影响。
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