通过CHF-吡唑啉的光化学分解合成CHF取代的3-氮杂双环[3.1.0]己烷。
Synthesis of CHF-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF-pyrazolines.
作者信息
Zheng Yang, Yu Xinling, Lv Songyang, Mykhailiuk Pavel K, Ma Qiang, Hai Li, Wu Yong
机构信息
Key Laboratory of Drug-Targeting of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University Chengdu 610041 China
Enamine Ltd. Matrosova 23 01103 Kyiv Ukraine
出版信息
RSC Adv. 2018 Jan 29;8(10):5114-5118. doi: 10.1039/c7ra13141k.
A practical synthesis of CHF-substituted 3-azabicyclo[3.1.0]hexanes was developed for the first time. The key step was photochemical decomposition of CHF-substituted pyrazolines. This protocol has the advantages of simple operation, and mild conditions, as well as excellent functional group tolerance, giving the desired products in moderate to excellent yields.
首次开发了一种实用的合成CHF取代的3-氮杂双环[3.1.0]己烷的方法。关键步骤是CHF取代的吡唑啉的光化学分解。该方法具有操作简单、条件温和以及对官能团耐受性优异的优点，能以中等至优异的产率得到所需产物。
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