黄酮类化合物作为血管舒张剂的合成及生物学评价
Synthesis and biological evaluation of flavonoids as vasorelaxant agents.
作者信息
Chen Zhiwei, Hu Yongzhou, Wu Haohao, Jiang Huidi
机构信息
Department of Medicinal Chemistry, Zhejiang University, School of Pharmaceutical Science, Hangzhou 310031, PR China.
出版信息
Bioorg Med Chem Lett. 2004 Aug 2;14(15):3949-52. doi: 10.1016/j.bmcl.2004.05.061.
PMID:15225704
Abstract
Several 5,7-dihydroxyflavone and quercetin 3-O-glycosides have been synthesized and evaluated for vasorelaxant activity. A log P-activity relationship amongst flavonoids was suggested.
摘要
已合成了几种5,7 - 二羟基黄酮和槲皮素3 - O - 糖苷，并对其血管舒张活性进行了评估。研究表明了黄酮类化合物之间的log P - 活性关系。
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