正丁基苯酞衍生物的合成与生物活性。
Synthesis and biological activity of n-butylphthalide derivatives.
机构信息
College of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
出版信息
Eur J Med Chem. 2010 May;45(5):1941-6. doi: 10.1016/j.ejmech.2010.01.036. Epub 2010 Jan 25.
PMID:20133025
Abstract
A series of n-butylphthalide derivatives were designed and synthesized. The in vitro activities of these compounds were evaluated by a resting tension of isolated rat thoracic aorta ring assay. Compounds 4g and 4i were found to be more active than n-butylphthalide.
摘要
设计并合成了一系列正丁基苯酞衍生物。通过离体大鼠胸主动脉环张力测定法评估了这些化合物的体外活性。发现化合物 4g 和 4i 比正丁基苯酞更具活性。
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