DNA修复基因XRCC1多态性、吸烟与食管癌风险
DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk.
作者信息
Yu Hong-Ping, Zhang Xiao-Yong, Wang Xiao-Li, Shi Lu-Yuan, Li Yuan-Yuan, Li Fang, Su Yan-Hua, Wang You-Jie, Lu Bin, Sun Xi, Lu Wen-Hong, Xu Shun-Qing
机构信息
Institute of Environmental Medicine, Tongji Medical College of Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China.
出版信息
Cancer Detect Prev. 2004;28(3):194-9. doi: 10.1016/j.cdp.2004.01.004.
To investigate the effect of X-ray repair cross complementing 1 (XRCC1) genetic polymorphisms on esophageal cancer risk, we determined XRCC1 polymorphisms at codon 194 (Arg --> Trp) and codon 399 (Arg --> Gln) in 135 patients with esophageal squamous cell carcinoma (ESCC) and 152 normal controls from hospitals. Although polymorphism at codon 194 was not associated with risk for ESCC, we found that the frequency of XRCC1 399 Gln/Gln genotype in ESCC patients (14.1%) was significantly higher than that in normal controls (3.3%), and that XRCC1 399 Gln/Gln genotype was associated with an increased risk of ESCC (odds ratio (OR) = 5.15, 95% confidence interval (CI): 2.42-0.93). In addition, we found that the risk for smoker increased 4.2-fold than non-smokers in the 399 Gln/Gln genotype (OR = 4.20, 95% CI: 2.37-7.44). These results suggest that XRCC1 399 Gln/Gln genotype may contribute to the risk of ESCC and modify risk associated with smoking.
为了研究X射线修复交叉互补基因1（XRCC1）基因多态性对食管癌风险的影响，我们测定了来自医院的135例食管鳞状细胞癌（ESCC）患者和152例正常对照者第194密码子（Arg→Trp）和第399密码子（Arg→Gln）处的XRCC1多态性。虽然第194密码子处的多态性与ESCC风险无关，但我们发现ESCC患者中XRCC1 399 Gln/Gln基因型的频率（14.1%）显著高于正常对照者（3.3%），且XRCC1 399 Gln/Gln基因型与ESCC风险增加相关（比值比（OR）=5.15，95%置信区间（CI）：2.42 - 0.93）。此外，我们发现399 Gln/Gln基因型吸烟者的风险比非吸烟者增加了4.2倍（OR = 4.20，95% CI：2.37 - 7.44）。这些结果表明，XRCC1 399 Gln/Gln基因型可能会增加ESCC风险，并改变与吸烟相关的风险。
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