粘性盐溶液：源自北极海绵粘胶软海绵的新型3-烷基吡啶生物碱。

Viscosaline: new 3-alkyl pyridinium alkaloid from the Arctic sponge Haliclona viscosa.

作者信息

Volk Christian A, Köck Matthias

机构信息

Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12, D-27570 Bremerhaven, Germany.

出版信息

Org Biomol Chem. 2004 Jul 7;2(13):1827-30. doi: 10.1039/b403413a. Epub 2004 Jun 7.

DOI:10.1039/b403413a

PMID:15227533

Abstract

Polycyclic pyridinium alkaloids are widely distributed in several sponges of the order Haplosclerida. So far, studies on Haliclona and related genera were mainly concentrated on warm or tropical waters. Here, we describe the chemical investigation of the Arctic sponge Haliclona viscosa and structure elucidation of the acyclic 1,3-dialkyl pyridinium alkaloid viscosaline. A novel structural motif of viscosaline is that beta-alanine is covalently bound to one alkyl chain.

摘要

多环吡啶生物碱广泛分布于单轴海绵目（Haplosclerida）的几种海绵中。到目前为止，对Haliclona属及相关属的研究主要集中在温暖或热带水域。在此，我们描述了北极海绵Haliclona viscosa的化学研究以及无环1,3 - 二烷基吡啶生物碱粘菌素的结构解析。粘菌素的一个新结构基序是β-丙氨酸与一条烷基链共价结合。