天然来源的首个环状单体3-烷基吡啶生物碱：鉴定、合成及生物活性
The first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources: identification, synthesis, and biological activity.
作者信息
Timm Christoph, Volk Christian, Sasse Florenz, Köck Matthias
机构信息
Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12, D-27570, Bremerhaven, Germany.
出版信息
Org Biomol Chem. 2008 Nov 7;6(21):4036-40. doi: 10.1039/b808647h. Epub 2008 Sep 9.
DOI:10.1039/b808647h
PMID:18931812
Abstract
3-Alkylpyridine alkaloids are very common secondary metabolites from marine sponges of the order Haplosclerida. Here, we report on the identification and synthesis of the first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources. Due to the lack of a pure sample of the new compound, structure elucidation had to rely on HPLC and MS(n).
摘要
3-烷基吡啶生物碱是来自单轴海绵目海洋海绵的非常常见的次生代谢产物。在此，我们报道了从天然来源首次鉴定和合成环状单体3-烷基吡啶鎓生物碱。由于缺乏新化合物的纯样品，结构解析不得不依赖于高效液相色谱法和质谱(n)。
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